In this episode, host Brandon Miller is joined by Dr. Matthew Jorgensen and Dr. Helin Räägel. Dr. Jorgensen, a board-certified toxicologist with a Ph.D. in chemistry, serves as Nelson Laboratory’s Chemistry and Materials Scientist. Dr. Räägel, with a Ph.D. in cell biology, is Nelson Labs’ Senior Biocompatibility Expert. Together, they provide an in-depth education on pre-clinical testing and biocompatibility for medical devices, focusing specifically on cytotoxicity testing.
Brandon, Matt, and Helin take a deep dive into the intricacies of cytotoxicity testing, a critical component in the biocompatibility assessment of medical devices. They explain the importance of cytotoxicity testing in ensuring that medical devices do not release harmful substances that could damage cells upon contact. This type of testing is fundamental to verifying the safety of medical devices before they reach clinical trials and eventually the market.
Listeners will gain insights into the methodologies used in cytotoxicity testing, including in vitro assays that evaluate the potential cytotoxic effects of medical devices on mammalian cells. Matt and Helin discuss the standards and protocols that guide these tests, ensuring that the devices meet rigorous safety criteria.
The episode also highlights common challenges and considerations in cytotoxicity testing, offering practical advice for navigating the complexities of pre-clinical testing. By understanding these principles, manufacturers and researchers can better prepare their devices for regulatory approval and market entry.
This episode is part of the Intro into Biocompatibility podcast series and is essential for professionals involved in the development and testing of medical devices. Tune in to deepen your understanding of cytotoxicity testing and its role in ensuring the safety and efficacy of medical devices.